瘦素受体基因3057位G→A变异与妊娠高血压综合征的关系

Relationship between the variation 3057 nucleotide G→A of exon 20 of leptin receptor gene and the pathogenesis pregnancy induced hypertension syndrome in Chinese population

目的探讨瘦素受体基因(Leptin receptor gene,LEPR)20外显子3057位核苷酸G→A变异与妊娠高血压综合征(妊高征,PIHs)关系。方法应用PCR-RFLP法检测了106例妊高征患者(妊高征组)和98例正常妊娠孕妇(对照组)LEPR基因3057位核苷酸G→A变异。结果妊高征组LEPR基因型频率分布:GG型为2.8%,GA型为16.1%,AA型为81.1%;妊高征组AA基因型频率和A等位基因频率(81.1%和89.1%)高于对照组孕妇(74.5%和85.2%),但无统计学意义(P>0.05);携带A等位基因和AA基因型的孕妇发生PIHs的相对风险OR值分别为1.43(95%CI:0.79～2.56)和1.72(95%CI:0.28～10.75)(P>0.05)。结论LEPR基因3057位G→A变异与潍坊地区汉族人群PIHs的发病无明显相关性。

Objective：To investigate relationship between the variation 3057 nucleotide G→A of exon 20 in the leptin receptor gene（LEPR）and the pathogensis of group.The variation 3057 nuleotide G→A of exon 20 in the LEPR gene was detected by polymerase chain reaction-restriction fragment length polymorphism analysis.Results：The genotype frequencies of LEPR gene in PIHs group was 2.8% for GG,16.1% for GA and 81.1% for AA respectively.The AA genotype and A allele frequencies（81.8% and 89.1%）in PIHs group were higher than those （74. 5% and 85.2% ） in normal controls, but no statistically significant differences （ P 〉 0. 05 ）. The odds ratio for the carriers with A allele in PIHs group was 1.43 （95% CI ： 0. 79 - 2. 56, P 〉 0. 05 ）, whereas for the AA genotype, the odds ratio was 1.74 （95%CI： 0.78 -3.94, P 〉0. 05）, compared with he GG genotype. Conclusion： Our data indicate that LEPR gene 3057 nucleotide G→A variation may not be significantly associated with PIHs in Chinese Han nationality.