血管紧张素原基因多态位点AGT174与原发性高血压相关性的研究

Correlation between the Polymorphism of Angiotensinogen Gene at Position 174 and Essential Hypertension

本文采用ＰＣＲ、限制性酶切和电泳分型等方法，分别对９０例原发性高血压患者和１０９例正常人血管紧张素原基因多态位点ＡＧＴ１７４进行了检测，结果表明，高血压组中三种基因型的分布与对照组显著不同，提示该位点变异与原发性高血压的发生相关。

The polymorphism of angiotensinogen gene at position 174 was studied in 90 cases of essential hypertension patients and 109 controls by PCR, restriction enzyme analysis and electrophoresis methods The results showed the distribution of genetypes in hypertension group was significantly different from that of controls group This suggested there is a correlation between the variant of AGT174 and hypertension