Raf-1蛋白激酶在细胞信号转导研究中的新进展

Research Progress of Raf1 Protein Kinase in Signal Transduction

重点讨论Ｒａｆ１蛋白激酶的特征、激活方式及其与其他蛋白质相互作用等方面的研究进展．Ｒａｆ１蛋白激酶是酪氨酸激酶相关信号转导途径中的重要信号分子之一，可直接下传与Ｒａｓ蛋白相关的细胞增殖信号．近年来发现，Ｒａｆ１蛋白激酶还可与其他信号分子作用或相互调节，参与多种细胞生物学过程的信号转导与调控．

Raf1 protein kinase has been known as an important component of Ras/Raf1/MAPK signaling pathway related to cell proliferation. It also may be a crosstalk point among different signal transduction pathways. This is a review about the characteristics of Raf1 molecule, its activation and relationship with other proteins.