测定尿假尿苷和肌酐对卵巢癌诊断价值的探讨

Study of urinary pseudouridine and creatinine in the diagnosis of ovarian tumors.

目的：探讨肿瘤标记物假尿嘧啶核苷（ｐｓｅｕｄｏｕｒｉｄｉｎｅＰＤ，简称假尿苷）对卵巢癌的临床价值。方法：采用反相高效液相色谱法（ＨＰＬＣ）快速测定卵巢癌、良性卵巢肿瘤和正常对照妇女尿液的假尿苷和肌酐（ＵＲ）含量。结果：卵巢癌病人尿假尿苷／肌酐（ＰＤ／ＵＲ）显著高于良性卵巢肿瘤和正常对照者（Ｐ＜００１）。尿ＰＤ／ＵＲ在卵巢癌组的阳性率为９２８％，良性卵巢肿瘤组为１７４％，正常对照组无一例阳性。结论：测定尿ＰＤ／ＵＲ对卵巢癌的筛查、诊断和监测是一个简便易行、快速可靠的方法。

Objective:To determine the clinical value of tumor marker pseudouridine to ovarian carcinoma.Methods:Urinary pseudouridine and creatinine concentration were rapidly evaluated in control subjects and patients with malignant and benign ovarian turmor by high-performance liquid chromatography(HPLC).Results:The urinary pseudouridine/Creatinine in patients with malignant ovarian tumor was significantly higher than that in controls and patients with benign ovarian tumor(P<0 01).The urinary pseudouridine/creatinine was positive in 97 8% of patients with malignant ovarian tumor,17 4% of patients with benign ovarian tumor,none of controls.Conclusions:Measuring urinary PD/UR is a simple,rapid and credible method in screening,diagnosing and monitoring malignant ovarian tumor.