妇科住院患者酵母样真菌感染的菌株分布与药敏研究

Research on the distribution and drug sensitivity of yeast-like fungi from gynecoloyical inpatients' vaginal secretion

目的对妇科住院患者阴道分泌物酵母样真菌隐性感染的菌群分布与药敏结果进行回顾性分析,为临床围手术期合理使用抗真菌药物提供依据。方法妇科住院患者5813例阴道分泌物中分离到396株酵母样真菌,采用API-20Aux和ATBFUNGUS进行鉴定和药敏试验。结果396株酵母样真菌中,分离率最高的前3位是白色假丝酵母菌(59.6%)、光滑假丝酵母菌(21.2%)和接合假丝酵母菌(6.6%)。酵母样真菌对5-氟胞嘧啶(5-FC)、两性霉素B(AMB)和制霉菌素(NYS)敏感率最高,达90.7%、92.7%和96.2%,咪康唑(MIC)、益康唑(ECO)和酮康唑(KET)分别为74.2%、61.6%和69.4%。结论住院妇科患者阴道分泌物酵母样真菌隐性感染主要以白色念珠菌和光滑念珠菌为主,感染的酵母样真菌对5-FC、AMB和NYS的药物敏感性较高,对唑类抗真菌药则有不同程度的耐药率。

Objective To retrospectively analyse the distilbution and drug sensitivity of the strains of yeasts isolated from the gynecologycal inpatients＇ vaginal secretion. Method 396 strains of yeasts isolated from 5813 gynecologycal inpatients＇ vaginal secretion were identified by using the AP 1-20Aux and ATBFUN GUS. Result The most common isolates in the 396 strains of yeasts were Candida albicans （ 59.6% ） , Candida glabrata （21.2% ） and joint- Yeastlike （ 6.6% ） respectively ; The drug sensitivity to 5-Fluorocytosine （ 5-FC ）, Amphotericin B （ AMB）, Nystatin （ NYS）, Miconazole （ MIC）, Econazole Nitrate （ECO）, Keteconazole （KET） were 90.7% ,92.7% ,96.2% ,74.2o% ,61.6% and 69.4% respectively. Conclusion Vaginal Candidasis is usually caused by Candida albieans and Candida glabrata. The strains of yeasts isolated are more susceptive to 5-Fluorocytosine （5-FC）, amphotericin B （AMB） and Nystatin （NYS） while resistent to zole drugs to various extents.