肺心病急性期血浆内皮素-1含量昼夜变化及临床意义

The change round the clock and the clinical importance of plasma endothelin-1 contents in cor pulmonale patients during acute stages

目的观察慢性肺源性心脏病（肺心病）急性期患者血中内皮素－1（endothelin－1，ET－1）含量昼夜变化，探讨其临床意义。方法用放射免疫法测定36例肺心病急性期患者和31例正常人8时、16时、24时血浆ET－1含量，并比较二组血浆ET－1含量的昼夜变化。结果肺心病急性期患者血浆ET－1值8时、24时最低（分别为57．45±10．32，38．47±12．15ng／L，P＜0．01）。患者血浆ET－1值在各时间均显著高于健康人。结论肺心病急性期患者血浆ET－1具有昼夜节律变化，且昼夜均处于高水平。这对肺心病的进一步防治有一定意义。

Objectives To study the change round the clock of plasma endothelin - 1 (ET - 1 ) contents and probed into its clinical impor-tance in cor pulmonale patients during acute stages. Methods The contents of ET - 1 were detected by radioimmunoassay (RIA) at 8,16, and 24th hour in 36 patients and 31 normal people, and the contents of the two groups were contrasted with each other. Results The contents of ET - 1 in the patients were the highest at 8th hour, the lowest at 24th hour (57. 45 ± 10. 32ng/L, 38. 47±12. 15ng/L respectively, P < 0. 01), and they were higher than those of the normal people at all the observing times. Conclusion The change of ET - 1 contents in cor pulmonale patients during acute stages has a regular pattern round the clock, and they keep a high level. this may have some help for further prevention and treatment of cor pulmonale.