直肠癌根治术中动脉灌注化疗的临床应用

Arterial perfusion chemotherapy in radical resection of rectal cancer

目的：探讨直肠癌根治术中动脉灌注化疗的临床意义。方法：灌注组３２例，术中经直肠上动脉灌注氟脲嘧啶（５Ｆｕ）和丝裂霉素（ＭＭＣ）；对照组２０例仅作常规手术。统计两组伤口感染、裂开、吻合口瘘和造瘘口坏死回缩的发生率及手术前后ＷＢＣ、ＲＢＣ、ＢＰＣ、ＡＬＴ和ＢＵＮ的变化。结果：两组均无腹部切口感染、裂开，无吻合口瘘和造瘘口坏死；会阴切口感染率灌注组和对照组分别为１８．２％和２０％；ＷＢＣ、ＲＢＣ、ＢＰＣ、ＡＬＴ、ＢＵＮ灌注组手术前和对照组差异均无显著性（Ｐ＞０．０５）。结论：术中动脉灌注化疗无严重毒副作用，不增加术后并发症，是直肠癌有效的辅助治疗措施。

Objective:To study the effects of arterial perfusion chemotherapy in radical resection of rectal cancer.Methods:52 cases were divided into two groups:perfusion group(32 cases) and control group(20 cases).5 Fu and MMC were dripped into arterial rectalis superior together with operation in perfusion group and routine operation only in control group.Postoperative complications,such as wound infection,laceration,anastomotic leakage,colonic necrosis and changes in WBC,RBC,BPC,ALT and BUN before and after operation were observed.Results:No abdominal wound infection occurred in both two groups.Perineum incision wound infection is seen only in 18.2% of perfusion group and 20% of control group.The difference in WBC,RBC,BPC,ALT and BUN of two groups before and after operation were not significant( P >0.05).Conclusions:No serious side effect and no increase in postoperative complications is seen after arterial perfusion chemotherppy,therefore it is an efficient supplementary therapy.