微创血肿清除术对脑出血患者血清NSE水平的影响

Effect of mini-invasive hematoma aspiration on content of NSE in patients with cerebral hemorrhage

目的探讨微创血肿清除术对脑出血患者血清神经元特异性烯醇化酶(NSE)水平的影响。方法住院脑出血患者80例,随机分为微创手术组38例和保守治疗组42例。在入院当时及2,4,7,14d各留取血液标本1次,测定血清中神经元特异性烯醇化酶(NSE)的水平。在入院时和7、14、21d进行欧洲卒中量表(ESS)和日常生活能力(ADL)评分。结果脑出血患者入院时血清NSE含量即有升高,微创组与保守组NSE水平均在2d达到高峰,4、7、14d时微创组NSE水平低于保守组(P<0.05),微创组神经功能缺损和生活能力神经功能缺损和生活能力评分明显高于保守组(P<0.05)。结论微创穿刺血肿清除术能降低ICH患者血清NSE水平,减轻神经损伤,促进神经功能恢复。

Objective To observe the effect of mini-invasive hematoma aspiration on changes of serum NSE concentrations in patients with acute cerebral hemorrhage. Methods 80 patients were divided into aspiration treatment group and conservative treatment group. Serum NSE concentration was measured at hospital admission and on 2d,4d,Td and 14d after symptom onset. The European Stroke Scale（ESS） and Activities of Daily Living Scale（ADL） were evaluated at hospital admission and 7d, 14d and 21d after symptom onset. Results The serum level of NSE increased significantly at hospital admission. Peak serum level of NSE was found at 2d. NSE in aspiration treatment group was significantly lower than conservative treatment group at 4d,7d and 14d（ P 〈 0.05 ）. The EES and ADL was significantly higher in aspiration group than those in conservative group（P 〈 0.05）. Conclusion Mini-invasive hematoma aspiration for cerebral hemorrhage can decrease the serum the NSE level. The aspiration can reduce brain damage in the treatment of intracerebral hemorrhage.