摘要
对30例食管癌初诊患者于手术或放化疗前一周内进行18F-FDGPET/CT检查,将15例手术治疗患者的130枚区域淋巴结的PET/CT结果与病理学检查相比较。所有患者的远处转移灶及15例非手术治疗患者的区域淋巴结转移根据活组织病理学检查、多种影像学检查临床随访而定,随访时间均大于6个月。结果显示:30例食管癌患者,原发病灶18F-FDGPET/CT均为高代谢病灶(100%),病灶界限显示清晰。以患者为单位计算,30例食管癌患者,20例(66.7%)证实有区域淋巴结转移,18F-FDGPET/CT真阳性18例,假阳性2例,假阴性2例,诊断的灵敏度、特异性和准确性分别为90.0%、80.0%、86.7%。以淋巴结为单位计算,在15例手术治疗患者的共130枚淋巴结中,病理学检查证实为淋巴结转移33枚(25.4%),PET/CT真阳性23枚。18F-FDGPET/CT对区域淋巴结转移诊断的灵敏度、特异性及准确性分别为69.7%、97.9%、90.8%。检出远处转移4例(13.3%),分布于肝脏、肺及骨骼。30例PET/CT显像后,16例提高了临床分期;1例降低了临床分期;13例与18F-FDGPET/CT显像前的临床分期一致。
PET/CT scan was performed for 30 newly diagnosed esophageal carcinoma patients within the week before operation and radio- and/or chemo-therapy. The diagnosis of esophageal carcinoma was established according to the histopathology examination. In 15 patients with operation, the findings of PET/CT of 130 regional lymph nodes were compared with the histopathology examination. The distant metastasis of all patients and the regional lymph node metastasis of 15 patients without operation were diagnosed by the pathological examination, other imaging findings or/and clinical follow up for over 6 months. The results show that all the primary lesions had very intense ^18F-FDG uptake. The sensitivity of PET/CT was 100%. The lymph nodes metastasis was proved in 20 patients （66.7%）. PET/CT was true positive in 18 patients, false positive in 2 patients. The sensitivity, specificity and accuracy of PET/CT were 90.0%, 80.0% and 86.7%, respectively, based on the case study. In 130 excised lymph nodes of 15 patients with the operation, 23 of 33 lymph nodes metastasis were detected by PET/CT. The sensitivity, specificity and accuracy of PET/CT were 69.7%, 97.9% and 90.8%, respectively, based on the lesion study. PET/CT detected the distant metastasis in the liver, lung and bone in 4 cases. After PET/CT imaging, the staging of tumor in 16 patients was improved, 1 was lowered, and 13 was concord with pre-staging. ^18F-FDG PET/CT plays an important role in the diagnosis and staging for esophageal cancer.
出处
《核技术》
CAS
CSCD
北大核心
2009年第11期849-853,共5页
Nuclear Techniques
基金
国家自然科学基金(30870731)资助
