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纳米结晶在难溶性药物口服给药中的应用 被引量：12

Application of Nanocrystal Technology for Poorly-soluble Drug Oral Administration
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摘要 药物纳米结晶除药物外不含基质材料。微粒粒径小于1μm。本文简介其理化性质和临床优点,并着重阐述了制备技术和作用原理。 Nanocrystal drugs with diameter less than 1 μm are composed of active pharmaceutical ingredient without matrix material. This article brings a brief introduction on physicochemical properties and clinical merits of nanocrystal drugs, and mainly focuses on nanocrystal preparation technology and mechanism.
作者 张熹 金方
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2009年第11期851-855,共5页 Chinese Journal of Pharmaceuticals
关键词 纳米结晶 难溶性药物 制备 综述 nanocrystal poorly-soluble drug preparation review
分类号 R944.9 [医药卫生—药剂学]
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参考文献25

  • 1Kayser O, Lemke A, Hernandez-Trejo N. The impact of nanobiotechnology on the development of new drug delivery systems [J]. Curt Pharm Biotechnol, 2005, 6(1) : 3-5.
  • 2Lindfors L, Skantze P, Skantze U, et al. Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth [J]. Langmuir, 2007, 23 (19) : 9866-9874.
  • 3Moschwitzer J, Muller RH. New method for the effective production of ultrafine drug nanocrystals [J]. J Nanosci Nanotechnol, 2006, 6(9-10) : 3145-3153.
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  • 8Lindfors L, Skantze P, Skantze U, et al. Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening [J]. Langmuir, 2006, 22 (3) : 906-910.
  • 9Langguth P, Hanafy A, Frenzel D, et al. Nanosuspension formulations for low-soluble drugs: pharmacokinetic evaluation using spironolactone as model compound [J]. Drug Dev IndPharm, 2005, 31 (3): 319-329.
  • 10Gao L, Zhang DR, Chen MH. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system [J]. J Nanoparticle Res, 2008, 10 (5) : 845-862.

共引文献8

同被引文献181

引证文献12

二级引证文献53

中国医药工业杂志
2009年 第11期

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