摘要
蛋白质组学技术被广泛的用于阿尔茨海默氏病(AD)的研究中。本文综述了已发现的AD脑组织、外周组织和动物模型中蛋白质差异表达和翻译后修饰变化,结合生物信息学分析结果,初步阐明了参与AD发病机制的关键蛋白质及其信号通路,为深入研究AD的病理生理机制和治疗提供了依据。
Proteomics technologies have been widely used in investigation of Alzheimer＇s disease （AD）. Classical methods with protein separation follow by identification provide a convenient platform for quantification of protein level and detection of modification. With the application of novel protein microarrays, mass spectrometry, biochemistry and molecular biology, proteomics technologies show great potentials to study the mechanism of AD and drug targets. We analyzed different protein expression and posttranslational modification found in AD brain, peripheral tissues and animal models. The changed protein function and the main pathway involved were discussed. This article provided new understanding of biochemistry, pathology, and physiology of AD and also supplied insight into potential molecular mechanism of AD.
出处
《现代生物医学进展》
CAS
2009年第18期3594-3597,共4页
Progress in Modern Biomedicine
