异氟醚控制性降压期间血流动力的变化——与硝普钠对比分析

Hemodynamic Changes during Controlled Hypotension by Isoflurane——A Comparative Study with Sodium Nitroprusside

本文用心阻抗血流图对比研究了异氟醚、硝普钠控制性降压期间血流动力的变化。结果表明,50～60％N_2O-O_2-异氟醚麻醉下加深异氟醚施行控制性降压(n=20)中,MAP、TPR、TTI分别下降40.7～43.8％、42.8～43.8％、42.1～44.1％、SV、CI、HI无明显下降,HR增加12～17％,ECG缺血性改善较少,静脉普鲁卡因复合麻醉下SNP降压(n=22)中,MAP、TTI和TPR的变化与异氟醚相似,但HR增快明显,SV下降和ECG缺血性改变较多,且存在反跳性TPR升高和CI减少。结论:异氟醚降压在一定程度上优于SNP,值得临床推广应用。

With impedance cardiography, the hemodynamic changes during controlled hypotension induced by either isoflurane or sodium nitroprusside (SNP) were studied comparatively. MAP, TPR and TTI were reduced by40.7%-43.8%, 42.8%-43.8% and 42.1-44.1%, resp(?)ctively, SV, CI and Heather index did not change significantly and HR increased 12-17% during hypotension induced by high concentration of isoflurane (1.23-1.24MAC) with 50-60% N_2O-O_2-isoflurane anesthesia. Under intravenous procaine balanced anesthesia, SNP-induced hypotension caused similar changes to isoflurane in MAP, TPR and TTI but the increase of HR, decreases of SV and CI and ischemic change in electrocardiography were more. It is concluded that isoflurane has more advaniages over SNP in contolled hypotension.