不同剂量的罗库溴胺用于气管插管的安全性及有效性评估

Safety and availabitity evaluation using for tracheal intubation different doses rocuronicm

目的本研究从插管时间、插管反应、不良反应三方面对434例应用罗库溴胺快速诱导气管插管患者进行临床评价。方法选择全身麻醉手术患者434例,随机分为两组,I组罗库溴胺0.6mg.kg-1(2ED95);Ⅱ组罗库溴胺0.9mg.kg-1(3ED95)。麻醉诱导:两组分别给予咪唑安定0.04mg.kg-1;芬太尼0.04mg.kg-1;丙泊酚2mg.kg-1;0.6/0.9mg.kg-1相应剂量罗库溴胺诱导插管。记录插管时间及插管反应和不良反应。结果应用0.6mg.kg-1罗库溴胺和应用0.9mg.kg-1罗库溴胺插管起效时间无显著差异(P>0.05),插管反应发生的机率也无显著差异(P>0.05)。结论0.6mg.kg-1罗库溴铵能满足快速诱导插管需求,且插管反应和不良反应无显著表现。

OBJECTIVE To evaluate 434 patients who induced tracheal intubation quickly with rocuronium from times and intubation reaction and adverse effect. METHODS 434 patients with different ages under general anesthesia were randomized to use rocuronium for tracheal intubation containing 0.6mg.kg^-1 or 0.9mg.kg^-1, Supplying simultaneously 0.04mg.kg^-1 midazolam and fentanyl and 2mg.kg^-1 propofol. Recording the times and intubation reaction and adverse effects. RESULTS patients had no significant deviation for intubation times and intubation reaction in groupI and Ⅱ （P 〉0.05）. CONCLUSION Using 0.6mg.kg^-1 rocuronium could induce tracheal intubation quickly and had no significant with intubation reaction and adverse effect.