螺旋CT分析胃间质瘤的转移特征与疗效的关系

Spiral CT Analysis for Relationship between Metastic Characteristics and Therapeutic Effect of Gastric Stromal Tumors with Metastasis

目的探讨螺旋CT分析胃间质瘤(gastric stromal tumors,GST)的转移特征和疗效的关系。资料与方法搜集资料完整的GST转移患者22例,回顾性分析和总结该病的转移特征,并评价伊马替尼治疗效果。结果22例GST转移患者中,肝转移13例,脾转移6例;腹壁切口区软组织转移及腹膜、胸膜转移3例;腹膜及盆腔转移4例;淋巴结转移2例;3例CT示有淋巴结肿大,病理证实为轻度反应性增生或轻度慢性炎症改变。伊马替尼治疗11例,多因素分析表明伊马替尼治疗为影响转移性GST患者生存时间的重要因素。结论GST淋巴结转移少见,主要以血行转移为主,并有一定的种植转移概率,伊马替尼近期疗效满意。

Objective To evaluate the value of spiral CT in analyzing metastic characteristics and therapeutic effect of gastric stromal tumors（GST） with metastasis.Materials and Methods A completely clinic history data of 22 patients with metastic GST were collected,metastic features were retrospectively analyzed,and the therapeutic effect of imatinib was evaluated.Results Of the metastic 22 GST,hepatic metastasis in 13,splenic metastasis in 6;soft tissue metastasis around the incision of anterior abdominal wall and pleural metastasis in 3,cavitas pelvis metastasis in 4,lymph node metastasis in 2,pathological results of chronic inflammation or reactive hyperplasia had been confirmed in CT findings of the 3 cases with lymphadenectasis.11 cases were treated with imatinib,Multivariate analysis showed that the administration of imatinib was an important factor on prolonging GST with metastasis.Conclusion GST rarely metastasize to lymph nodes,but can metastasize through blood stream,and sometimes metastasize to regional organs by planting,the near curative effect with imatinib is satisfaction.