经肝动脉化疗栓塞结合体部伽玛刀治疗肝癌的临床疗效分析

The Analysis of Transcatheter Arteral Chemoembolization Combined with Body Gamma Knife for Hepatocellular Carcinoma

目的探讨经肝动脉化疗栓塞(TACE)结合立体定向体部伽玛刀治疗肝癌的临床疗效。资料与方法将原发中晚期肝癌52例分为A、B两组。A组:30例,采用单纯TACE术,且行TACE术均在2次以上;B组:22例,采用TACE+体部伽玛刀治疗,先行TACE术1～3次后,再进行体部伽玛刀放射治疗,单次剂量为36～44 Gy。并观察比较肿瘤治疗后的近期疗效、患者生存期及并发症。结果A、B两组近期治疗总有效率分别为56.7%(17/30)和86.3%(19/22);患者1年生存率分别为70.0%和90.9%,中位生存期为11.2个月和15.5个月;两组并发症无明显差别。结论TACE结合体部伽玛刀治疗原发性肝癌是一种安全、有效的方法。

Objective To evaluate therapeutic efficacy of transcatheter arteral chemoembolization（TACE）combined with radiotherapy-body gamma knife in the treatment of hepatocellular carcinoma（HCC）.Materials and Methods 52 patients with HCC were randomly divided into two groups.30 of the 52 patients（A group） were simply treated with beyond two times TACE.22 of the 52 patients（B group）were treated with TACE for 1-3 times after given radiotherapy-body gamma knife 2-3 weeks.The therapeutic effect,survival rate and complication of the patients were assessed.Results The total effective rate were 56.7%（17/30） and 86.3%%（19/22） in A and B group respectively,1-year survival rates were 84.6%（22/30） and 57.7%（15/22） respectively.There was no significant difference of complications in two groups.Conclusion Transcatheter arteral chemoembolization（TACE）combined with radiotherapy-body gamma knife is a safe and effective method for hepatocellular carcinoma.