同型半胱氨酸与老年男性骨密度相关性分析

Clinical study on correlation between serum total homocysteine and bone mineral density in elderly men

目的探讨血清总同型半胱氨酸(tHcy)与老年男性骨密度(BMD)的相关性。方法选择109例年龄≥60岁老年男性为研究对象,采用乳胶增强散射比浊法测定纳入患者的血清总同型半胱氨酸(tHcy),用双能X线测定腰椎前后位总体及股骨总体骨密度(BMD),根据T≤-2.5,-2.5<T≤-1.0,T>-1.0分别分为骨质疏松症组、骨量低下组、正常组;评价各组间tHcy的差异,及tHcy与两部位BMD的相关性。结果①腰椎前后位总体及股骨总体骨质疏松组、骨量低下组及正常组之间tHcy差异均无显著性(P>0.05)。②tHcy与两部位BMD均无直线相关(r=0.27,P=0.778;r=-0.086,P=0.374)。结论tHcy与两部位BMD无直线相关,tHcy与骨质疏松性骨折间的关系可能独立于BMD和其他潜在的骨折危险因素。

Objective The aim of this study was to explore the correlation between serum total homocysteine level and bone mineral density （BMD） in elderly men. Methods Serum levels of tHcy （Latex enhanced nephelometry） and B MD[ by dualenergy X-ray absorptiometry（DEXA） ]of the anteroposterior spine （L1-4） and total femur were measured in 109 elderly men aged over 60years. All the patients were divided into osteoporosis group, osteopenia group and normal group according to T ≤ - 2.5 ; - 2.5 ≤ T ≤ - 1 ; T 〉- 1. Evaluate the inter-group differences in tHcy and the correlation between tHcy and BMD. Results （ 1 ） The osteoporosis group, osteopenia group and normal group had no significant differences in serum levels of tHcy （ P 〉 0.05 ）. （2） tHcy was no rectilinear correlation with BMD of anteroposterior spine （L1-4 ） and total femur. Conclusion The relationship between tHcy and osteoporosis fractures may be independent of BMD and others risks of osteoporosis.