骨质疏松与动脉粥样硬化相关发病机制的研究进展

The development of the mechanism and treatment between osteoporosis and atherosclerosis

骨质疏松与动脉粥样硬化是两种多因素退行性疾病,已成为重要的公共健康问题。两种疾病的发生率随着年龄的增长而增加,具有相同的危险因素和病理生理机制,其共同的保护性因素包括基质Gla蛋白,Wnts,雌激素,和维生素D/K等,而骨桥蛋白,骨形态发生蛋白,脂质氧化和炎症反应等参与或加速了二者的共同发病。基于两者相似的发病机制,改变生活方式,使用他汀类药物、双膦酸盐、血管紧张素转换酶抑制剂、利尿剂等药物可同时对骨量丢失和血管疾病起保护作用。

Osteoporosis and atherosclerosis, two multifactorial and degenerative diseases, are major public health problems. These diseases accompany the aging process, sharing common risk factors and several common pathophysiological factors. The protective factors include matrix Gla protein, Wnts, estrogen, as well as vitamin D and K, while osteoponsin, bone morphogenic protein, lipid oxidation products and inflammatory process, participate or accelerate these diseases. Changing the life style, using of statins, biphosphonates, ACEI and thiazides based on the biological linkage of the above entities may benefit both bone and vascular.