肝X受体对获得性免疫反应及NOR-1的调节作用

Acquired Immune Response and Regulation of NOR-1 by Liver X Receptor

肝X受体（liver X receptor，LXRs）是核受体超家族成员，能被氧化的胆固醇衍生物结合并激活，在胆固醇逆向转运中起着非常重要的作用。LXRs在人体的代谢和炎症中都有重要作用。现从获得性免疫反应中LXRs通过调控胞膜的重要组成物质-胆固醇胞内水平，从而抑制T细胞增殖的方向，在硫转移酶2B-肝X受体-膜转运体G1（SULT281-LXR—ABCG1）轴线上探讨LXRs对获得性免疫的调节作用，以及LXRs对神经元衍生孤核受体（NOR-1）的调控作用，以进一步认识LXRs的调控功能。

Liver X receptors （LXRs） are a member of the nuclear receptor superfamily. LXRs can be activated by association with oxidized cholesterol derivatives, thereby playing an important role in reverse cholesterol transport. In addition, LXRs play important roles in both human metabolism and inflammation. In order to further understand regulatory function of LXRs, this review elucidates the inhibition of T cell proliferation by LXRs in acquired immune response via controlling intracellular cholesterol level, and discusses the modulation of neurons derived orphan nuclear receptor （ NORA ） by LXRs based on the complex of SULT2B1-LXR-ABCG1.