原发性高血压早期肾损害患者血清效应性T淋巴细胞亚群特征因子的变化

The levels of cytokines secreted by effector T cells in hypertensive patients with early kidney injury

目的:探讨血管紧张素Ⅱ(ATⅡ)、干扰素γ(IFN-γ)、白细胞介素(IL)-4及IL-17水平与原发性高血压患者早期肾损害的关系。方法:68例原发性高血压患者依据尿白蛋白排泄率检测结果分为早期肾损害组和无肾损害组,健康体检者24例作为对照组。采用放射免疫法检测血浆ATⅡ水平,ELISA法检测血清中IFN-γ、IL-4和IL-17水平。结果:早期肾损害组ATⅡ、IFN-γ和IL-17水平增高,与无肾损害组和对照组相比差异有统计学意义;3组IL-4水平变化小,差异无统计学意义;ATⅡ水平与IFN-γ、IL-17水平呈正相关,而与IL-4水平无相关性。结论:原发性高血压患者的高ATⅡ水平使效应性T淋巴细胞亚群活性发生变化,导致Th1、Th17的功能上调与早期肾损害的发生和发展。

Objective：To evaluate the relationship between the levels of IFN-γ, IL-4 , IL-17 and early kidney injury in patients with hypertension. Methods： Sixty-eight hypertensive patients were divided into two groups by u- rinary albumin excretion rate（UAER） ： group one consisting of 22 cases with early kidney injury and group two consisting of 46 cases without kidney injury. The control group consists of 24 cases without hypertension and kid- ney injury. The levels of plasma angiotensin II were measured using radioimmunoassay and that of IFN-γ, IL-4 and IL-17 were measured using ELISA. Results： Angiotensin Ⅱ , IFN-γ and IL-17 levels were found to be sharply in- creased in group one compared with group two and the control group. The levels of IL-4 were no difference. The levels of angiotensin II were positively correlated with the levels of IFN-γ and IL-17 and negatively correlated with the levels of IL-4. Conclusions.. High angiotensin Ⅱ in the patients of hypertension induced the upregulation of Th1 and Th17,which promoted early kidney injury.