期刊文献+

糖尿病并发冠心病与内脂素的关系

原文传递
导出
摘要 目的:探讨血清内脂素水平与糖尿病并发冠心病的关系。方法:将69例2型糖尿病患者根据冠状动脉造影管腔直径是否狭窄(50%)及狭窄是否超过70%分为冠状动脉阴性组(27例),非显著狭窄组(19例)和显著狭窄组(23例),并入选正常对照者(25例)分别测定内脂素浓度并进行比较。结果:冠状动脉显著狭窄组血清内脂素浓度显著高于对照组和冠状动脉阴性组(P<0.01)。但冠状动脉非显著狭窄组和显著狭窄组之间内脂素浓度差异无统计学意义(P>0.05)。结论:糖尿病患者血清内脂素水平与冠心病发生及病变严重程度显著相关。
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2009年第10期752-753,共2页 Journal of Clinical Cardiology
  • 相关文献

参考文献7

  • 1王欣,刘芳,贾伟平.一种新发现的脂肪细胞因子——内脂素[J].上海医学,2007,30(3):221-222. 被引量:15
  • 2CHEN M P, CHUNG F M, CHANG D M, et al. Elevated plasma level of visfatin pre- B- cell colony enhancing factor in patients with type 2 diabetes mellitus [J]. J Clin Endocrinol Metab, 2006, 91:295--299.
  • 3FUKUHARA A, MATSUDAM, NISHIZAWAM, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin [J]. Science, 2005, 307 : 426-430.
  • 4LOPEZ-BERMEJO A, CHICO-JULIA B, FERNAN- DEZ-BALSELLSM, et al. Serum visfatin increases with regressive beta cell deterioration [J]. Diabetes, 2006, 55:2871--2875.
  • 5DAHL T B, YNDESTAD A, SKJELLAND M, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization[J]. Circulation, 2007, 115:972-980.
  • 6JIA SH, LI Y,PARODO J, et al. Pre-I3-cell colonyenhancing factor inhibit neutrophil apoptosis in experimental inflammation and clinical sepsis[J]. J Qin Invest ,2004,113:1318--1327.
  • 7RONGVAUX A, SHEAR J,MULKS M H, et al. pre-B-cell colony-enhancing factor, whose expression is up regulated in activated lymphocytes, is a nicotinamide phosplibo-syltransferase, a cytosolic enzyme involved in NAD biosynthesis[J]. Eur J Immunal, 2002, 32:3225--3234.

二级参考文献13

  • 1Samal B,Sun Y,Stearns G,et al.Cloning and characterization of the cDNA encoding a novel human pre-B-cell colonyenhancing factor.Mol Cell Biol,1994,14:1431-1437.
  • 2Jia SH,Li Y,Parodo J,et al.Pre-B-cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinicsl sepsis.J Clin Invest,2004,113:1318-1327.
  • 3Fujiki K,Shin DH,Nakao M,et al.Molecular cloning and expression analysis of the putative carp(Cyprinus carpio)pre-B-cell enhancing factor.Fish Shellfish Immunol,2000,10:383-385.
  • 4Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin:a protein secreted by visceral fat that mimics the effects of insulin.Seience,2005,307:426-430.
  • 5Muller WE,Perovic S,Wilkesman J,et al.Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with xenogeneic sponge molecule(s).DNA Cell Biol,1999,18:885-893.
  • 6Ognjanovic S,Bryant-Greenwood GD.Pre-B-cell colony-enhancing factor,a novel cytokine of human fetal membranes.Am J Obstet Gynecol,2002,187:1051-1058.
  • 7Jia SH,Li Y,Parodo J,et al.Pre-B-cell colony-enhancing factor inhibits neutrophil apoptosis in exoerimental inflammation and clinical sepsis.J Clin Invest,2004,113:1318-1327.
  • 8Kralisch S,Klein J,Lossner U,et al.Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytesc.J Endocrinol,2005,185:R1-R8.
  • 9Kralisch S,Klein J,Lossner U,et al.Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes.Am J Physiol Endoerinol Metab,2005,289:E586-E590.
  • 10Choi KC,Ryu OH,Lee KW,et al.Effect of PPAR-alpha and-gamma agonist on the expression of visfatin,adiponectin,and TNF-alpha in visceral fat of OLETF rats.Bio chem Bio phys Res Commun,2005,336:747-753.

共引文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部