摘要
一系列高分辨率的核糖体及其30S、50S亚基的晶体结构揭示了这个极其复杂的蛋白质翻译机器的重要作用机理,对在分子水平上了解生命机体产生和形成的一个基本环节(蛋白质合成)具有重大意义,同时为新型抗生素的设计与研发开辟了新方向新途径,对人类健康与生命保障具有重要作用.
The 2009 Nobel Prize in Chemistry was awarded to Venkatraman Ramakrishnan, Thomas A. Steitz, and Ada E. Yonath "for studies of the structure and function of the ribosome". The atomic-resolution ribosome structures solved by the laureates revealed the structural basis of the mechanisms ofpeptide syntheses by ribosome. They demystified several long standing functions of ribosome, such as the high fidelity of the translation process and the wobble effect. Their work also paved ways for the development of new antibiotics, just when public health is faced with increasing threat from drug-resistant pathogenic bacteria.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2009年第10期1239-1243,共5页
Progress In Biochemistry and Biophysics
关键词
核糖体
结晶
结构
功能
ribosome
crystallization
structure
function