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肺动脉平滑肌的氯离子通道

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摘要 正常肺动脉压力为15～30mmHg／5～10mmHg（1mmHg=0．133kPa），平均压力为10～20mmHg。动脉收缩压〉30mmHg者称为肺动脉高压。虽然对于肺动脉高压的研究已有100多年历史，但是其发病机制至今尚未完全明确。
作者 曾闵 庞玉生
机构地区 广西医科大学第一附属医院儿科
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2009年第10期947-949,共3页 Chinese Journal of Cardiology
基金 广西自然科学基金（桂科自0991133）
关键词 肺动脉平滑肌 氯离子通道 肺动脉压力 肺动脉高压 动脉收缩压 发病机制
分类号 R686 [医药卫生—骨科学]
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参考文献19

  • 1Sztrymf B,Yaici A, Jais X, et al. Genetics of pulmonary arterial hypertension: recent data and practical applications. Rev Mal Respir, 2005.22:796-805.
  • 2胡大一,荆志成.规范肺动脉高压的筛查诊断与治疗[J].中华心血管病杂志,2007,35(11):977-978. 被引量：18
  • 3Mandegar M, Remillard CV, Yuan JX. Ion channels in pulmonary arterial hypertension. Prog Cardiovasc Dis, 2002, 45 : 81-114.
  • 4Jentsch TJ, Steinmeyer K, Schwarz G. Primary structure of Torpedo marmorata chloride channel isolateted by expression cloning in Xenopus oocytes. Nature,1990,348:510-514.
  • 5Jentsh TJ, Stein V, Weinreich F, et al. Molecular structure and physiological function of chloride channels. Physiol, 2002,82:503-568.
  • 6Chen TY. Structure and function of CICchannels. Annu Rev Physiol, 2005,67:809-839.
  • 7Restrepo CM, Pineda L, Rojas-Martinez A, et al. CFTR mutations in three Latin American countries. Am J Med Genet, 2000,91:277-279.
  • 8Chipperfield AR, Harper AA. Chloride in smooth muscle. Prog Biophys Mol Biol, 2000,74 : 175-221.
  • 9Jackson WF. Ion channels and vascular tone. Hypertension, 2000, 35:173-178.
  • 10Leblanc N, Ledoux J, Saleh S, et al. Regulation of calciumactivated chloride channels in smooth muscle cells: a complex picture is emerging. Can J Physiol Pharmacol, 2005,83:541-556.

二级参考文献14

  • 1Karaki H,Ozaki H,Hori M,et al.Calcium movements,distribution,and functions in smooth muscle[J].Pharmacol Rev,1997,49(2):157-230.
  • 2Dipp M,Nye PC,Evans AM.Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle[J].Am J Physiol,2001,281(2):L318-L325.
  • 3Grynkiewicz G,Poeine M,Tsien RY.A new generation of Ca^2+ indicators with greatly improved fluorescence properties[J].J Biol Chem,1985,260(6):3440-3450.
  • 4Carl A,Lee HK,Sanders KM.Regulation of ion channels in smooth muscles by calcium[J].Am J Physiol,1996,271(40):C9-C34.
  • 5Post JM,Gelband CH,Hume JR.[Ca^2+]i inhibition of K^+ channels in canine pulmonary artery[J].Circ Res,1995,77(1):131-139.
  • 6Large WA,Wang Q.Characteristics and physiological role of the Ca^2+-activated Cl-conductance in smooth muscle[J].Am J Physiol,1996,271(1):C435-C454.
  • 7Wellman GC,Nelson MT.Signaling between SR and plasmalemma in smooth muscle:sparks and the activation of Ca2+-sensitive ion channels[J].Cell Calcium,2003,34(3):211-229.
  • 8Rubin LJ. Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest,2004,126(1 Suppl) :7S-10S.
  • 9Simonneau G, Galie N, Rubin LJ, et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol, 2004,43 (12 Suppl S) :5S-12S.
  • 10Barst RJ, McGoon M, Torbicki A, et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol, 2004, 43(12 Suppl S) :40S-47S.

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中华心血管病杂志
2009年 第10期

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