甘肃省裕固族人群ACAT2基因多态性与原发性高血压及血脂水平的关系

Relationship between the polymorphism of ACAT2 gene with essential hypertension and blood lipids in Yugu minority of Gansu Province

目的:探讨甘肃省裕固族人群酰基辅酶A:胆固醇酰基转移酶2(ACAT2)基因734C/T多态性与原发性高血压(EH)及血脂水平的关系.方法:裕固族原发性高血压患者102例,对照组l12例,应用聚合酶链反应-限制性片段长度多态性(PCR-RELP)技术分析ACAT2基因第7外显子734C/T多态性,同时测定血脂水平.结果:ACAT2基因734C/T各基因型频率分布在高血压组与对照组之间的差异无统计学意义(χ2=4.544,P=0.103),而高血压组T等位基因频率分布低于对照组,差异具有统计学意义(χ2=4.025,P=0.045).高血压组各基因型之间血脂水平差异均无统计学意义(P>0.05).结论:734T等位基因可能具有减少裕固族原发性高血压病发生的作用.ACAT2-734C/T基因多态性与裕固族高血压患者空腹血脂水平无明显相关性.

AIM：To investigate the relationship between the 734C/T polymorphism of acyl-coenzyme A：cholesterol acyltransferase2（ACAT2）gene with essential hypertension（EH）and blood lipids in Yugu minority of Gansu Province.METHODS：Polymerase chain reaction restriction fragment length polymorphisms（PCR-RELP）technique was used to analyze the 734C/T polymorphism.The blood lipids were also measured.The study covered 102 hypertensives and 112 controls of Yugu minority.RESULTS：The distribution of genotype frequencies of ACAT2 gene 734C/T polymorphism in hypertensives was similar to that in controls（χ2=4.544,P=0.103）.The T allele of 734C/T was significantly lower in hypertensives（χ2=4.025,P=0.045）.However,the level of blood lipids of ACAT2 genotype in hypertensives was no significant difference（P〉0.05）.CONCLUSION：The T allele of 734C/T may be protective against essential hypertension in Yugu minority.The ACAT2 gene 734C/T polymorphism was not affect the level of fasting blood lipid in hypertensives of .Yugu minority.