Hp感染与血清前列腺素E变化的关系

Changes of the levels of serum prostaglandin in the infenction of Helicobacter pylori

目的研究人体感染幽门螺杆菌(helicobacter pylori,Hp)后血清前列腺素E(prostaglandin E,PGE)的变化。方法用14C-呼吸试验和快速尿素酶试验检测HP阳性患者,对50例HP阳性的浅表性胃炎患者用放免法查治疗前后血浆前列腺素E的水平。结果HP阳性患者血清PGE浓度为(51.12±18.1)pg/ml,明显高于HP阴性患者血清PGE的浓度。而HP阳性患者根治后血清PGE水平由(51.12±18.1)pg/ml降为(17.98±8.15)pg/ml,接近HP阴性患者的水平。结论HP感染可以使胃黏膜保护因子PGE的生成增加。其在胃黏膜损伤中的机制需要进一步研究。

Objective To study the changes of levels of serum prostaglandin E （PGE） in patients with Helicobacter pylori（HP） infection. Methods The levels of PG were determined before and after eradication of HP in 50 HP positive patients with superficial gastritis, Results The level of PG was （51.12 ±18.1） pg/ ml in HP positive patients, which was significantly higher than that in HP negative patients. In HP positive patients, the level of PGE was significantly decreased from （51.12 ± 18.1 ） pg/ml to （ 17.98±8.15） pg/ml after eradication of HP, close to the level of HP negtive patients. Conclusion HP infection can promote the production of PGE, a protective factor of gastric mucosa. The pathogenesis of HP infection in damaging gastric mncosa requires further study.