期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

铁在帕金森病发病机制中的作用及其MRI测量 被引量：5

Iron accumulation in Parkinson’s disease and MRI measurement
下载PDF
导出
摘要 大量研究均证实帕金森病病人黑质铁异常沉积,随着对铁氧化应激损伤认识的深入,铁在帕金森病发病机制中的作用日益受到研究者的重视。MRI是唯一可以在活体定量检测脑铁含量的技术,在帕金森病的诊断、治疗及疗效随访中具有潜在的重要价值。就铁在脑内的代谢、在帕金森病中的病理机制及MRI定量测量的研究进展予以综述。
作者 张静 张云亭
机构地区 天津医科大学总医院放射科 兰州大学第二医院放射科
出处 《国际医学放射学杂志》 2009年第4期343-346,共4页 International Journal of Medical Radiology
关键词 铁 帕金森病 磁共振成像
分类号 R445.2 [医药卫生—影像医学与核医学] R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献29

  • 1Connor JR,Snyder BS,Beard JL,et al.Regional distribution of iron and iron-regulatory proteins in the brain in aging and disease[J].J Neurosci Res,1992,31:327-335.
  • 2Henle ES,Luo Y,Linn S.Fe2+,Fe3+,and oxygen react with DNA-derived radicals formed during iron-mediated Fenton reactions[J].Biochemistry,1996,35:12212-12219.
  • 3Sofic E,Riederer P,Heinsen H,et al.Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain[J].J Neural Transm,1988,74:199-205.
  • 4Griffiths PD,Dobson BR,Jones GR,et al.Iron in the basal ganglia in Parkinson's disease.An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy[J].Brain,1999,122:667-673.
  • 5Double KL,Gerlach M,Youdim MB,et al.Impaired iron homeostasis in Parkinson's disease[J].J Neural Transm Suppl,2000,60:37-58.
  • 6Gerlach M,Double KL,Youdim MB,et al.Potential sources of increased iron in the substantia nigra of parkinsonian patients[J].J Neural Transm Suppl,2006,70:133-142.
  • 7Dringen R,Bishop GM,Koeppe M,et al.The pivotal role of astrocytes in the metabolism of iron in the brain[J].Neurochem Res,2007,32:1884-1890.
  • 8Oakley AE,Collingwood JF,Dobson J,et al.Individual dopaminergic neurons show raised iron levels in Parkinson disease[J].Neurology,2007,68:1820-1825.
  • 9Tribl F,Asan E,Arzberger T,et al.Identification of L-ferritin in neuromelanin granules of the human substantia nigra-a targeted proteomics approach[J].Mol Cell Proteomics,2009,Mar 24[Epub ahead of print].
  • 10Crompton DE,Chinnery PF,Fey C,et al.Neuroferritinopathy:a window on the role of iron in neurodegeneration[J].Blood Cells Mol Dis,2002,29:522-531.

同被引文献71

  • 1李宝芹 ,刘焯霖 ,王玉凯 ,宁玉萍 ,刘平 ,谢安木 .Fe^(3+)与PC12细胞α-synuclein蛋白聚集关系的研究[J].中华神经科杂志,2004,37(4):299-299. 被引量：1
  • 2王劲,张雪林,邱士军,张玉忠,单鸿.磁共振成像评估帕金森病脑铁的临床应用研究[J].中华神经科杂志,2006,39(5):337-339. 被引量：6
  • 3Zhang Z X, Anderson D W, Huang J B, et al. Prevalence of Parkinson's disease and related disorders in the elderly population of greater Beijing, China[J]. Lancet, 2005,365(9459) :595-597.
  • 4Samii A, Nutt J G, Ransom B R. Parkinson's disease[J]. Lancet, 2004,363 (9423) :1783-1793.
  • 5McMillan D E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions [ J ]. Neurotoxicology, 1999,20(2-3) :499- 507.
  • 6Binolfi A, Rasia R M, Rasia R M, et al. Interaction of alpha- synuelein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement[J]. J Am Chem Soc,2006,128(30):9893-9901.
  • 7Gorell J M, Peterson E L, Rybicki B A, et al. Multiple risk factors for Parkinson's disease[J]. J Neurol Sci,2004,217(2): 169-174.
  • 8Perl D P, Olanow C W. The neuropathology of manganese- induced Parkinsonism[J]. J Neuropathol Exp Neurol, 2007,66 (8) :675-682.
  • 9Haacke E M, Cheng N Y, House M J, et al. Imaging iron stores in the brainusing magnetic resonance imaging[J]. Magn Reson Imaging,2005,23(1) : 1-25.
  • 10Zecca L, Youdin M B, Riederer P, etal. Iron, brain ageing and neurodegenerative disorders [J]. Nat Rev Neuro Sci, 2004,5 (5) :863-873.

引证文献5

二级引证文献44

国际医学放射学杂志
2009年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部