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化学交换饱和转移类对比剂在磁共振成像中的研究进展 被引量：3

Research progress of CEST agent in MR imaging
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摘要 新型对比剂的开发和研究是分子成像领域研究的热点之一。化学交换饱和转移（CEST）是一类阴性磁共振成像对比剂，与传统的阴性对比剂不同的是，CEST通过转移饱和质子达到减低水分子的信号T1和T2＋）而产生阴性对比。使用CEST不仅可以观察活体组织的结构改变，还可以进行代谢显像、标记细胞成像和pH值测定等。就CEST作为分子成像对比剂的成像原理、应用及研究现状予以综述。
作者 吴春苗 靳激扬
机构地区 东南大学附属中大医院放射科
出处 《国际医学放射学杂志》 2009年第5期475-477,共3页 International Journal of Medical Radiology
关键词 对比剂 分子成像 磁共振成像 化学交换饱和转移
分类号 R445.2 [医药卫生—影像医学与核医学] R973.9 [医药卫生—药品]
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参考文献23

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同被引文献25

  • 1Zhou J, Payen JF, Wilson DA, et al. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med ,2003,9:1085-1090.
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  • 7Ersoy H, Rybicki FJ. Biochemical safety profiles of gadolinium- based extracellular contrast agents and nephrogenic systemic fibrosis. J Magn Reson Imaging,2007,26:1190-1197.
  • 8Broome DR. Nephrogenic systemic fibrosis associated with gadol- inium based contrast agents: a summary of the medical literature reporting. Eur J Radiol,2008 ,66 :230-234.
  • 9Guivel-Scharen V, Sinnwell T, Wolff SD, et al. Detection of proton chemical exchange between metabolites and water in biological tissues. J Magn Reson ,1998 ,133 :36-45.
  • 10Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J Magn Reson,20G0,143:79-87.

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国际医学放射学杂志
2009年 第5期

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