虫白蜡还原法制备高级烷醇混合物研究

Preparation of Policosanol from Insect Wax by Reduction Method

通过虫白蜡还原法制备高级烷醇混合物探索研究，得到虫白蜡制备高级烷醇混合物的工艺优化条件：10g虫白蜡还原制备高级烷醇，氢化铝锂用量0．7g，四氢呋喃溶剂用量70mL，在65℃、常压和超声波作用条件下，进行还原反应5h后，用水煮沸洗涤2-3次，过滤，滤饼烘干，虫白蜡转化率可达到95％-98％。用有机溶剂重结晶高级烷醇混合物后，用气相色谱测定组成为二十六烷醇56％、二十八烷醇32％、二十四烷醇5．2％、三十烷醇4．0％、二十五烷醇1．5％、二十七烷醇0．9％。

Policosanol was prepared from insect wax reduced by LiAlH4. The optimized condition is： 0.7 g LiAlH4 and 70 mL tetrahydrofuran with 10 g wax, reaction temperature 65℃, atmospheric pressure and ultrasonic condition for 5 h for reducing reaction. The product was washed with boiling water for 2-3 times, then filtered and dried to obtain policosanol （crude） of 95 %-98 % yield. After recrystallizing the crude policosanol from organic solvent for 3 times and dried, the obtained policosanol has the composition of hexacosanol 56 %, octacosanol 32 %, tetracosanol 5.2 %, triacontanol 4.0 %, pentacosanol 1.5 %, heptacosanol 0.9 % by GC analysis.