转化生长因子β1及受体在胃癌实 虚证型中的表达

The Expression of TGFβ1 and TβRI in Gastric Cancer of Sthenia Syndrome and Asthenia Syndrome

目的:探讨转化生长因子β1及受体与实、虚证胃癌的关系。方法:设立实证组、虚证组和对照组,采用免疫组织化学方法,检测探讨转化生长因子β1及受体在各组中的表达。结果:TGFβ1在实证组、虚证组中的表达明显高于对照组,并且实证组>虚证组>对照组,3组比较有明显差异(P<0.05);TβRI在实证组、虚证组中的表达明显低于对照组(P<0.05),实证组<虚证组<对照组,但实证组与虚证组比较无明显差异(P>0.05)。结论:转化生长因子β1及受体是胃癌中医辩证依据之一,可以作为一种"邪"的参考指标。

Objective： To explore the relationship between TGFβ1, TβRI and gastric cancer of sthenia syndrome and as- thenia syndrome. Methods： Set up the groups of sthenia syndrome,asthenia syndrome and control; then respectively test their contents of TGFβ1 and TβRI by immunohistochemical method. Results： The expression strength of TGFβ1 in the group of sthenia syndrome and asthenia syndrome higher than that of control group, group of sthenia syndrome 〉 group of asthenia syndrome 〉 control group,there was significant difference among the three groups （ P 〈 0.05） ; For gastric canc- er of sthenia syndrome and asthenia syndrome,the levels of TβRI were averagely lower than that of control group ,group of sthenia syndrome 〈 group of asthenia syndrome 〈 control group, there was no significant difference between two group of gastric cancer（P 〉 0.05 ）. Conclusion： The TGFβ1 and TβRI are the important basis for differential diagnosis in tcm of gastric cancer , and it can be used as reference index for pathogenic factor.