核型BAG-1在早期乳腺癌的表达及其意义

Expression and significance of nuclear BAG-1 in early breast cancer

目的探讨核型BAG-1在早期乳腺癌组织中的表达与传统预后因素如临床病理特征、ER、PR、HER2的关系及其意义。方法用免疫组化二步法检测76例有完整随访资料的早期乳腺癌患者乳腺癌组织中核型BAG-1、ER、PR及HER2的蛋白表达,并进行统计学分析。结果核型BAG-1在早期乳腺癌组织中的阳性率为14.47%。核型BAG-1表达与患者的年龄、绝经状态、肿瘤的病理类型及HER2的蛋白表达无关(P>0.05),与ER、PR蛋白表达相关(P<0.05)。单因素分析显示核型BAG-1、ER、HER2与预后相关,多因素分析显示只有核型BAG-1表达与预后相关。结论核型BAG-1与ER、PR相关,可能作为早期乳腺癌预后判断的指标之一。

Objective To observe retrospectively the expression and significance of nuclear BAG-1 in early breast cancer（EBC） and its relationship with clinical pathological features and ER, PR, HER2. Methods A total of 76 patients with EBC were followed up in this study. The protein expressions of nuclear BAG-1, ER, PR and HER2 in these patients were detected by immunohistochemical two-step method and statistically analyszed. Results The positive rate of protein expression of nuclear BAG-1 was 14.47%. The protein expression of nuclear BAG-1 was not related to age, menopausal status, histology and HER2 （P 〉 0. 05）, but positively related to PR and ER（P 〈 0. 05 ）. Nuclear BAG-1 ,ER,HER2 were correlated with prognosis in univariate analysis with COX proportional hazard model. In multivariate analysis,only nuclear BAG-1 was correlated with prognosis. Conclusion The results of this small pilot study suggest that the protein expression of nuclear BAG-1 in EBC was correlated with ER and PR, that might be a novel prognostic biomarker.