雷公藤内酯醇对佐剂性关节组织MIP-1α RANTES和VEGF表达影响的实验研究

Effect of Triptolide on Expression of MIP-1α RANTES and VEGF in Adiuvant Arthritis in Rats

目的:探讨雷公藤内酯醇对佐剂性关节炎大鼠病变关节组织MIP-1α、RANTES和VEGF表达的影响。方法:在建立大鼠佐剂性关节炎模型基础上,给予不同剂量雷公藤内酯醇后,观察病变关节组织病理损害程度和MIP-1α、RANTES和VEGF免疫组织化学染色结果。结果:与模型组比较,3个雷公藤内酯醇治疗组关节肿胀度和病变关节组织MIP-1α、RANTES和VEGF表达明显减少,病变关节组织的病理损害明显改善。结论:雷公藤内酯醇可抑制佐剂性关节炎大鼠病变关节组织MIP-1α、RANTES和VEGF表达。

Objective： To study the inhibitory effects of Triptolide （TL） on expression of MIP -1α, RANTES and VEGF in adjuvant - induced arthritis rats. Methods ： Rat arthritis model waz induced by adjuvant, TL was given at does of 0. 1- 0.4mg/kg, The MIP-1α, RANTES and VEGF protein expression in arthritis tissue was examined by immunohisto- chemistry ,The macroscopical and histological changes of the arthrite were checked. Results： Compared with model group, the expression of MIP -1α, RANTES and VEGF were remarkably reduced, the macroscopical and histological changes were significantly improved in TL - treated rats （ P 〈 0.05,P 〈 0.01 ）. Conclusion： triptolide can inhibite production of MIP -1α, RANTES and VEGF in arthrits tissue of adjuvant induced rats.