摘要
目的:探讨参附强心合剂对心衰大鼠心室重塑及心肌AngⅡ受体AT1、AT2-mRNA表达的影响。方法:采用腹主动脉缩窄法制做心衰大鼠模型,观察参附强心合剂对左室重量与体重比(LVW/BW)及心肌组织AngⅡ受体AT1、AT2-mRNA表达的影响。结果:参附强心合剂可降低左室重量指数LVW/BW(P<0.01),下调AT1-mRNA表达,上调AT2-mRNA表达(P<0.05)。结论:参附强心合剂能降低左室重量指数LVW/BW,抑制心室肥厚;调节AT1、AT2表达,逆转心衰大鼠心肌重构的分子生物学改变;从而对慢性心衰有防治作用。
Objective： To investigate the influence of Shenfuqiangxin heji （SFQXHJ） on myocardial remodeling and the expression of AT1 ,AT2 - mRNA in chronic heart failure （CHF） rats. Methods： Using male adult SD rats made CHF models by coarctation of abdominal aorta（CAA）. To observe the effect of SFQXHJ on the left ventricular weight （LVW） /body weight （BW） ratio （LVW/BW） and the expression of AT1 ,AT2 -mRNA. Results： SFQXHJ could reduced LVW/ BW obviously（P 〈 0.01 ）, decreased the expression of AT1 -mRNA and increased the expression of AT2 -mRNA（ P 〈 O. 05）. Conclusion： SFQXHJ could reverse the changes in molecular biology of myocardial remodeling and inhibit ventric- ular hypertrophy, then could prevent CHF.
出处
《中华中医药学刊》
CAS
2009年第11期2429-2431,共3页
Chinese Archives of Traditional Chinese Medicine
基金
杭州市科技发展计划项目(LX2007)
