血浆同型半胱氨酸与老年高血压相关性研究

CORRELATION BETWEEN SEROUS HOMOCYSTEINE AND SENILE HYPERTENSION

目的:探讨血浆同型半胱氨酸(Hcy)与老年高血压病的关系。方法:采用高压液相色谱法测定96例高血压病患者及70例健康体检者血浆Hcy,放射免疫检测法测定叶酸及维生素B12水平。结果:老年高血压病组血浆Hcy水平(11.0±2.3umol/L)明显高于正常对照组(6.4±1.7umol/L),差异有统计学意义(p<0.001)。而叶酸(FA)、维生素B12低于健康者(均p<0.05)。结论:同型半胱氨酸水平升高可能是老年高血压病的原因之一,叶酸、维生素B12与同型半胱氨酸水平呈负相关。

OBJECTIVE： To study correlation between serous homocysteine （Hcy） and senile hypertension. METHOD ： Serous Hcy in 96 hypertension patients and 70 healthy individuals was detected by high performance liquid chromatography, and the level of folic acid and vitamin B12 were detected by radioimmunoassay for the investigated people. RESULTS ： Serous Hcy level （ 11. 0 ± 2. 3umol/1 ） in senile hypertension group was significantly higher than the control group （ 6. 4 ± 1. 7umol/L）, （ P 〈 0. 001 ）, but level of folic acid and vitamin B12 were remarkably lower than the healthy individuals （ P 〈 0. 001 ）. CONCLUSION： Hcy may be one of the factors resulting in senile hypertension. Folic acid and vitamin B12 are negatively correlated with Hcy.