摘要
目的:观察长效托宁在急性有机磷农药中毒(AOPP)中的治疗作用和疗效。方法:随机将口服有机磷农药中毒患者分为对照组和试验组。对照组应用氯解磷定和阿托品,试验组应用氯解磷定和长效托宁救治。结果:长效托宁可使轻、中、重度AOPP患者中毒症状持续时间缩短,M样症状时间分别为0.2h、0.5h、0.6h,对照组分别为1.4h、2.3h、4.0h;中枢神经系统症状时间分别为0.6h、4.5h、12.0h;对照组分别为10.5h、18.6h、21.3h;用药总量减少,分别为2.4mg、5.8mg、8.5mg;对照组分别为7.2mg、25.4mg、186.3mg;用药总次数减少,治疗组分别为2.1次、3.6次、6.2次;对照组分别为3.2次、12.8次、45.3次。两组比较,差异均有统计学意义(p<0.01)。结论:长效托宁是救治急性有机磷农药中毒的理想药物。
OBJECTIVE : To determine therapeutic effects of penehyclidime hydrochloride treating organophorsphorus pesticide poisoning (AOPP). METHOD : The patients of AOPP were randomly divided into two groups: control group and trial group. Pyraloximi methochloridum and atropine were administered in the control group, while pyraloximi methochloridum and penehyclidime hydrochloride were used in the trial group. RESULTS : Penehyclidime hydrochloride could shorten duration of poisoning symptom in mild to serious AOPP patients. M symptom lasted 0.2h, 0. 5h and 0. 6 h in the trial group and 1.4h, 2. 3h and 4. Oh in the control group; Symptom phase of central nervous system was 0. 6h, 4. 5h and 12.0 h with a contrast of 10. 5, 18. 6 and 21.3h in control group. The total sum of medicine applied was 2. 4mg, 5.8mg and 8. 5mg with a contrast of 7.2, 25.4 and 186. 3mg in control group. The times of medicine applied also reduced to 2. 1, 3.6 and 6. 2 times with a contrast of 3.2, 12. 8 and 45. 3 times in the control group. The differences of the two groups was significant ( p 〈 0. 01 ). CONCLUSION : Penehyelidime hydrochloride is an ideal medicine for treatment of AOPP
出处
《九江医学》
2009年第3期13-14,19,共3页
Jiujiang Medical Journal
关键词
有机磷农药中毒
长效托宁
阿托品
organophorsphorus pesticide poisoning
penehyelidime hydrochloride
atropine