长效托宁治疗急性有机磷农药中毒疗效观察

EFFECT OF PENEHYCLIDIME HYDROCHLORIDE TREATING ORGANOPHOSPHORUS PESTICIDE POISONING

目的:观察长效托宁在急性有机磷农药中毒(AOPP)中的治疗作用和疗效。方法:随机将口服有机磷农药中毒患者分为对照组和试验组。对照组应用氯解磷定和阿托品,试验组应用氯解磷定和长效托宁救治。结果:长效托宁可使轻、中、重度AOPP患者中毒症状持续时间缩短,M样症状时间分别为0.2h、0.5h、0.6h,对照组分别为1.4h、2.3h、4.0h;中枢神经系统症状时间分别为0.6h、4.5h、12.0h;对照组分别为10.5h、18.6h、21.3h;用药总量减少,分别为2.4mg、5.8mg、8.5mg;对照组分别为7.2mg、25.4mg、186.3mg;用药总次数减少,治疗组分别为2.1次、3.6次、6.2次;对照组分别为3.2次、12.8次、45.3次。两组比较,差异均有统计学意义(p<0.01)。结论:长效托宁是救治急性有机磷农药中毒的理想药物。

OBJECTIVE ： To determine therapeutic effects of penehyclidime hydrochloride treating organophorsphorus pesticide poisoning （AOPP）. METHOD ： The patients of AOPP were randomly divided into two groups： control group and trial group. Pyraloximi methochloridum and atropine were administered in the control group, while pyraloximi methochloridum and penehyclidime hydrochloride were used in the trial group. RESULTS ： Penehyclidime hydrochloride could shorten duration of poisoning symptom in mild to serious AOPP patients. M symptom lasted 0.2h, 0. 5h and 0. 6 h in the trial group and 1.4h, 2. 3h and 4. Oh in the control group; Symptom phase of central nervous system was 0. 6h, 4. 5h and 12.0 h with a contrast of 10. 5, 18. 6 and 21.3h in control group. The total sum of medicine applied was 2. 4mg, 5.8mg and 8. 5mg with a contrast of 7.2, 25.4 and 186. 3mg in control group. The times of medicine applied also reduced to 2. 1, 3.6 and 6. 2 times with a contrast of 3.2, 12. 8 and 45. 3 times in the control group. The differences of the two groups was significant （ p 〈 0. 01 ）. CONCLUSION ： Penehyelidime hydrochloride is an ideal medicine for treatment of AOPP