紫杉醇联合奥沙利铂治疗晚期胃癌27例疗效观察

Effects of combination of paclitaxel and oxaliplatin on advanced gastric cancer:clinical observation of 27 cases

目的:探讨紫杉醇联合奥沙利铂治疗晚期胃癌的疗效和毒副作用。方法:27例晚期胃癌患者均给予紫杉醇137～175mg/m2,第1天持续静脉泵入3h,奥沙利137～175mg/m2;第2天持续静脉泵入2h,21d为1周期,平均用药3～4周期。结果:全组27例均可评定疗效,获完全缓解(CR)1例、部分缓解(PR)15例、稳定(SD)6例、进展(PD)5例,总有效率为59.3%,临床抑制率为81.5%;对腹膜后淋巴结转移疗效最好,有效率为58.3%;主要毒副作用为骨髓抑制,神经毒性等。结论:紫杉醇联合奥沙利铂治疗晚期胃癌患者疗效较好,毒副作用轻,患者可耐受,值得临床推广应用。

Objective： To explore the efficacy of the combination of paelitaxel and oxaliplatin on advanced gastric cancer and its toxicity and side effects. Methods： 27 patients with advanced gastric cancer were treated with paclitaxel （137 mg/m^2-175 mg/m^2） and oxaliplatin （137 mg/m^2-175 mg/m^2） by continuous intravenous infusion for 3 h at the first day, and 2 h at the second day. 21 days of treatment was considered as a course and the average procedure for all patients was 3 to 4 courses. Results： According to the efficacy assessment, 1 out of the 27 cases was evaluated as complete remission, 15 were evaluated as partial remission, 6 as stable disease and 5 as progression disease. The total effective rate was 59.3% , clinical inhibition rate was 81.5%. The treatment showed the best effects on retroperitoneal lymph node metastasis cases with efficiency of 58.3%. The main toxicity were myelosuppression and neurological toxicity. Conclusion： The combination of paclitaxel and oxaliplatin is effective on advanced gastric cancer with light toxicity and few side effects, it＇s well tolerated and worthy to be popularized.