国内文拉法辛与三环类抗抑郁药治疗抑郁症引发口干、失眠、焦虑的Meta分析

Meta-analysis of differences on incidence of dry mouth,insomnia and anxiety induced by Venlafaxine and tricyclic antidepressants in the treatment of depression in domestic index

目的比较文拉法辛与三环类抗抑郁药物治疗抑郁症引发口干、失眠、焦虑的差异。方法对国内文拉法辛与三环类抗抑郁药物治疗抑郁症的对照研究进行全面调查,采用固定效应模型(FEM)法对符合标准的10项对照研究文献进行Meta分析。结果文拉法辛治疗抑郁症引发口干的出现率显著低于三环类抗抑郁药物[RR=0.20,95%CI(0.14～0.30)],P<0.01。文拉法辛治疗抑郁症引发失眠、焦虑的出现率显著低于三环类抗抑郁药物[RR=0.34,95%CI(0.21～0.56)],P<0.01。结论在治疗抑郁症中,文拉法辛治疗抑郁症引发的口干,焦虑和失眠副作用的出现率显著低于三环类抗抑郁药物,文拉法辛抗抑郁疗效优于三环类抗抑郁药物。

Objective To compare the Differences on incidence of dry mouth,insomnia and anxiety induced by venlafaxine and tricyclic antidepressants（TCA）. Methods A total of 10 controlled study on venlafaxine and tricyclic antidepressant drugs in the treatment of depression in domestic were analyzed by fixed effects model, meta-analysis of evidence-based medicine （EBM）. Results In the treatment of depression, incidence of dry mouth induced by venlafaxine venlafaxine group was significant lower than that of tricyclic antidepressants group [ RR = 0.20,95% CI （0.14--0.30） ] ,P 〈0.01. And the incidence of insomnia and anxiety induced by venlafaxine venlafaxine group was significant lower than that of tricyclic antidepressants group [ RR = 0.34,95% CI（0. 21-0. 56 ） ], P 〈 0.01. Conlusion In the treatment of depression, the incidence of dry mouth, insomnia and anxiety induced by Venlafaxine group was significant lower than tricyclic antidepressants group, and the efficacy of Venlafaxine is better than tricyclic antidepressants.