妊娠相关蛋白-A及C反应蛋白对不稳定型心绞痛的诊断意义

Significance of pregnancy-associated plasma protein-A and C-reactive protein for the diagnosis of unstable angina

目的探讨妊娠相关蛋白-A(PAPP-A)和C-反应蛋白(CRP)对不稳定型心绞痛(UA)的诊断意义。方法分别采用双抗体夹心酶联免疫吸附法和双抗体放射免疫法检测23例UA患者、21例稳定型心绞痛(SAP)患者和18名健康对照者的血浆PAPP-A和CRP浓度。结果UA组CRP和PAPP-A浓度明显高于SAP组和健康对照组(P<0.05)。SAP组和健康对照组CRP和PAPP-A浓度比较无明显差异性(P>0.05)。结论PAPP-A和CRP是UA的炎性标记物,可能是预测冠心病的危险程度的重要指标。

Objective To explore pregnancy-associated plasma protein-A （PAPP-A） and C-reactive protein （CRP） for the diagnosis of unstable angina（UA）. Methods 21 patients with stable angina pectoris （SAP） ,23 patients with UA and 18 healthy controls were enrolled. The level of serum PPAP-A was detected with double-antibody sandwich enzyme-linked immunosorbent assay （ELISA）, and serum level of CRP was detected with double antibody radioimmunoassay. Results CRP and PAPP-A in UA group were significantly higher than those in the normal control group and SAP group （ P 〈 0.05 ）. Compared with normal control group, CRP and PAPP-A levels in SAP had no significant difference （ P 〉 0.05 ）. Conclusion As two kinds of inflammatory markers, the level of serum PAPP-A and CRP in patients might predict the extent of the risk of coronary heart disease.