氨氯地平联合比索洛尔治疗肾性高血压23例

Amlodipine Combined with Bisoprolol for the Treatment of Renal Hypertension

目的观察氨氯地平联合比索洛尔治疗肾性高血压的疗效和安全性。方法将51例肾性高血压患者随机分为两组。对照组28例给予氨氯地平5.0mg,po,q12h;治疗组23例给予氨氯地平2.5～5.0mg,po,qd,同时给予比索洛尔2.5～5.0mg,po,qd。两组均连用8周。监测治疗前后血压、心率、肾功能等。结果对照组降血压总有效率67.9%,治疗组总有效率82.6%。两组患者治疗前后心率、肾功能等均无明显改变,无明显不良反应。结论氨氯地平联合比索洛尔治疗肾性高血压安全有效,其疗效优于单用氨氯地平。

Objective To evaluate the effects and safety of amlodipine combined with bisoprololin for the treatment of renal hypertension. Methods Fifty-one patients with renal hypertension were randomly divided into two groups. 28 Patients in the control group were treated with amlodipine 5.0 mg q12 h,while 23 in the treatment group were treated with amlodipine 5 mg qd and bisoprolol 2.5 - 5.0 mg qd for eight weeks. Blood pressure, heart rate and renal function were monitored before and after treatment. Results The total antihypertensive effective rates were 67.9% and 82.6% in the control and treatment group, respectively. There were no significant changes in heart rate and renal function before and after treatment in both groups and no obvious adverse events occurred. Conclusion Amlodipine combined with bisoprolol was efficient and safe for the treatment of renal hypertension, and was more effective than amlodipine used alone.