纳络酮治疗前庭神经元炎80例分析

To approach the Naloxone's Effect in 80 Vestibular Neuronitis

目的探讨纳络酮治疗前庭神经元炎(Vestibularneuronitis,VN)的临床疗效及安全性。方法将入选的158例VN患者,随机分成纳络酮治疗组80例和氟桂利嗪对照组78例,在常规镇静、止吐和皮质激素治疗基础上,治疗组给予纳络酮1.2mg/d静脉滴注,对照组给予氟桂利嗪10mg/d口服,3d为1疗程。结果治疗组治愈76例(治愈率95%),有效80例(有效率100%);对照组治愈53例(治愈率67.9%),有效68例(有效率87.1%),经PEMS3.1统计软件处理,治疗组的治愈率和总有效率明显优于对照组(P<0.01),且治疗组用药后取得明显疗效的时间小于对照组(P<0.05)。结论纳络酮治疗VN见效快,疗效好,副作用小。

Objective To explore the clinic therapeutic effect and safety of Naloxone in VN＇s treatment. Methods 158 VN patients were randomly divided into Naloxone group（80） and Flumarizine group（76）.The two groups both received corticosteroids, antivomit drugs and sedatives. The therapy group was treated by 1.2mg/d Naloxone ivgtt, the control group received 10mg/d Flunarizine po, three days were a course of treatment.Results 76 healed well in the therapy group（cure rate 95%）,80 showed improvement（effective rate 100%）.53 were cured in the control group（cure rate 67.9%）, 68 showed improvement（effective rate 87.1%）, analysed by PENS 3.1 statistics software, the cure rate of the therapy group are obviously higher than the control group（P〈0.01） and the therapy group get obvious herapeutic effect sooner than the control group（P〈0.05）.Conclusion Naloxone work faster in the VN＇s treatment, its curative effect is better, and the side effect is smaller.