神经元特异性烯醇化酶和C反应蛋白对急性脑梗死病情及预后的评价

Evaluation of neuron-specific enolase and C-reactive protein on the severity and prognosis of acute cerebral infarction

目的 探讨急性脑梗死患者血清神经元特异性烯醇化酶（NSE）和C反应蛋白（cRP）对其病情和预后的评估价值。方法测定92例急性脑梗死患者（观察组）和45例健康对照者（对照组）血清NSE和CRP水平，并分析观察组NSE和CRP水平与神经功能损害程度及梗死部位的关系。结果观察组血清NSE和CRP水平明显高于对照组（P〈0．01）。观察组采用美国国立卫生院卒中量表（NIHSS）评分，重型者NSE和CRP水平[（35．63±7．12）μg／L、（13．82±3．57）mg／L]显著高于轻、中型者[分别为（17．24±5．32）μg／L、（5．61±2．35）mg／L和（26．08±5．91）μg／L、（9．07±2．14）mg／L]（P〈0．01）。不同梗死部位患者血清NSE、CRP水平比较差异无统计学意义。结论NSE和CRP是反映脑内神经元损伤或坏死的客观指标，可作为脑梗死早期判断病情和预后的指标。

Objective To investigate the levels of serum neuron-specific enolase （NSE） and C- reactive protein （CRP） in patients with acute cerebral infarction, and its value on prognosis. Methods The levels of serum NSE and CRP were compared in 92 acute cerebral infarction patients （observation group） and 45 healthy （control group）. The relationship between the levels of NSE, CRP and the degree of neurological damage and infarction location were analyzed. Results The levels of serum NSE and CRP were significantly higher in observation group than those in control group （P〈 0.01 ）. In observation group, the levels of serum NSE and CRP were higher in heavy patients [ （35.63± 7.12） μg/L, （ 13.82± 3.57 ） mg/L ] than those in mild or medium patients [ （17.24 ± 5.32） μg/L, （5.61 ± 2.35） mg/L and （26.08 ±5.91 ） μg/L, （9.07 ±2.14） mg/L,respectively] （P 〈 0.01 ）. There was no significant difference in the levels of serum NSE and CRP in different infarction location（P〉 0.05）. Conclusion The level of serum NSE and CRP is an index in reflecting the degree of neurological damage, and they can be used in evaluating patient＇s condition and prognosis.