糖尿病早期周围神经病变患者神经传导速度及定量感觉检查检测分析

Analysis of nerve conduction velocity and quantitative sensory test in patients with early diabetic peripheral neuropathy

目的 探讨糖尿病早期周围神经病变的神经电生理特点。方法分别对175例无周围神经损害的糖尿病患者及50例健康人进行神经传导速度（NCV）及末梢感觉定量检查（QST）检测，并将结果进行对比分析。结果175例糖尿病患者中，NCV异常率为7％（13，175），QST异常率为45％（79／175），两者比较差异有统计学意义（P〈0．01）。糖尿病患者与健康人比较运动传导速度、感觉传导速度差异无统计学意义（P〉O．05）；QST阈值中的冷觉、温觉、热痛觉差异有统计学意义（P〈0．01）。结论对于糖尿病性周围神经病变QST较NCV的诊断敏感性高，提示其早期以小神经纤维受损更常见。

Objective To observe the characteristics of electro-neurophysiology in diabetic patients with early peripheral neuropathy. Method The nerve conduction velocity （NCV） and quantitative sensory test （QST） were examined in 175 diabetic patients without clinical peripheral neuropathy and in 50 normal subjects, and their results were compared. Results In 175 diabetic patients, the abnormal ratio of NCV was 7% （13/175）.While using QST,the abnormal ratio was 45% （79/175）. There was significant difference between two methods （P 〈 0.01 ）. Compared diabetic patients with normal subjects, there was no significant difference between motor conduction velocity and sensory conduction velocity （P 〉 0.05 ）.While using QST, the threshold values of cold sensation,warm sensation,and thermalgesia showed significant difference between diabetic patients and normal subjects （P〈 0.01 ）. Conclusion QST is more sensitive than NCV in diagnosing diabetic peripheral neuropathy,which suggests that small nerve fibers are more likely to be damaged than large fibers in early stage.