摘要
GATA家族是一族含锌指结构的转录调节因子,在人和哺乳动物中广泛表达,同时在器官形态发生、细胞的增殖和性别的分化中扮演着重要的角色。GATA-4和GATA-6在人类、小鼠、猪和鸡的卵巢和睾丸中被鉴定。GA-TA-4通过基因调节苗勒管的退化和雄激素的产生来促成雄性生殖腺的发育。GATA-4和GATA-6存在于小鼠胎儿的卵巢和睾丸的细胞中,并能够调节这些细胞的功能,尤其是卵巢的颗粒细胞、膜细胞、睾丸的支持细胞和间质细胞。GATA-4还存在于小鼠胎儿期和青春前期的生精细胞内。
The GATA family proteins are a group of zinc finger transcription factors that are expressed in human and mammalian animals and play an important role in mammalian organ morphogenesis,cell proliferation and sex differentiation.GATA-4 and GATA-6 have been identified in the ovaries and testes of humans,mice,pigs and chickens.GATA-4 contributes to fetal male gonadal development by regulating the genes that mediate Müllerian duct regression and the onset of testosterone production.GATA-4 and GATA-6 are localized in and regulate the function of the ovarian and testicular somatic cells of fetal mice,especially granulosa cells,thecal cells,Sertoli cells and Leydig cells.GATA-4 is also present in the germ cells of fetal and prepubertal mice.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2009年第10期932-936,共5页
National Journal of Andrology
基金
陕西省教育厅专项科研计划项目(07JK166
08JK504)~~
