摘要
目的:了解服用华法林患者抗凝过量和抗凝不足的原因。方法:收集我院2008年1月～9月95例服用华法林患者的年龄、性别、体质量、用药剂量、国际标准化比值(INR)、抗凝情况、合并用药情况等资料并进行分析。结果:患者的年龄、体质量影响华法林的剂量和抗凝效果;合用的药物中,左氧氟沙星增强华法林抗凝效果的作用最强;共进行480次INR监测,INR在目标范围2.0～3.0为332次,占69.2%。发生出血共7例,占7.4%。结论:影响华法林抗凝效果的因素很多,需对患者进行更严密的抗凝监测。
OBJECTIVE： To probe into the reasons behind the overanticoagulation and underanticoagulation in patients receiving warfarin. METHODS： 95 patients hospitalized in our hospital from Jan. to Sept. in 2008 were analyzed in respect of patients＇ age, gender, weight, dosage of warfarin, international normalized ratio（INR）, antieoagulation state, drug combination, etc. RESULTS： Patients＇ age and weight were correlated to the dosage and anticoagulative effect of warfarin, Levofloxacin was the most potent in enhancing the anticoagulative effect of warfarin. Of the 480 times of INR monitoring, the INR of 332 （69.2%） were within 2.0--3.0, and bleeding was noted in 7 cases （7.4%）. CONCLUSION： The anticoagulative effect of warfarin is associated with many factors; therefore, it is urgent to tighten antieoagulative monitoring.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第32期2527-2529,共3页
China Pharmacy
关键词
华法林
抗凝
国际标准化比值
Warfarin
Antieoagulation
International normalized ratio
