载脂蛋白B基因多态性对阿托伐他汀调脂疗效的影响

Effects of Polymorphism of Apolipoprotein B Gene on Lipid-regulating Efficacy of Atorvastatin

目的:观察载脂蛋白B(ApoB)基因多态性对低剂量阿托伐他汀调脂疗效的影响。方法:选择高脂血症患者211例,其中67例服用阿托伐他汀10mg,每晚1次;于治疗前及治疗开始后第4、8、12周抽血实验室检查血脂指标。采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLPs)方法检测ApoB基因XbaⅠ酶切位点基因多态性。结果:211例高脂血症患者中,X+等位基因相对频率为0.0853,X-等位基因相对频率为0.9147。服用阿托伐他汀4周后,携带X+X-基因型患者的总胆固醇(TC)降低百分率较X-X-基因型患者少(14.98%vs.19.39%,P<0.05)。结论:阿托伐他汀对携带X+等位基因的高脂血症患者的调脂疗效减弱。

OBJECTIVE： To evaluate the effect of polymorphism in Apo B gene on the lipid regulating efficacy of low dose of atorvastatin. METHODS： 221 patients with hyperlipidemia were enrolled, of whom, 67 were treated with oral atorvastatin （10 mg.d^-1） quaque nocte. The blood lipid indexes were measured before treatment and at 4, 8 and 12 weeks of treatment. The polymorphisms of Apo B gene on Xba Ⅰlocus were determined using PCR RFLPs method. RESULTS： Of the 211 patients, the relative frequency of X ＋ allele and X- allele were 0.085 3 and 0.914 7, respectively. After treatment with atorvastatin for 4 weeks, the TC reduction in X ＋ X - genotype carriers was less than in X - X - genotype carriers （14.98% vs. 19.39%, P （0.05） . CONCLUSION： Atorvastatin attenuates the lipid- regulating efficacy in hyperlipidemia patients carrying X ＋ allele.