甘露醇致不良反应文献分析

Literature Analysis of Adverse Drug Reactions Induced by Mannitol

目的:探讨甘露醇致不良反应的一般规律与特点。方法:检索《中国期刊全文数据库》1999～2008年甘露醇所致不良反应文献,并进行统计、分析。结果:甘露醇引起的不良反应共计135例,男性多于女性。所致不良反应最多为急性肾功能衰竭30例(22.22%),其次为过敏17例(12.59%)、休克17例(12.59%)。结论:临床上应加强甘露醇应用的监测,以减少不良反应的发生。

OBJECTIVE： To study the general pattern and characteristics of the adverse drug reactions （ADR） induced by mannitol. METHODS： The literature related to the ADR induced by mannitol reported during 1999-2008 retrieved from CNKI was analyzed statistically. RESULTS： A total of 135 mannitol - induced ADR cases were collected, of which, males showed higher proportion than females, and the ADRs chiefly manifested as acute renal failure（30 cases, 22.22% ）, followed by allergic reactions（17 cases, 12.59%） and shock（17 cases, 12.59%） . CONCLUSION： Clinicians should tighten monitoring on the use of mannitol to reduce the occurrence of mannitol- induced ADR.