应用霉酚酸酯治疗的肾小球疾病患者感染相关因素分析

Analysis of infection among patients with giomerular diseases treated with mycophenolate mofetile

目的探讨霉酚酸酯（MMF）治疗肾小球疾病的感染状况与相关因素。方法采用MMF治疗的肾小球疾病患者47例，分析24周内发生感染的情况以及相关因素。结果47例中肾病综合征39例，系统性血管炎8例，24周内发生感染者15例，以上呼吸道感染与肺部感染多见，最终3例死于肺部感染合并急性呼吸窘迫综合征（ARDS）。Logistic回归显示感染与肾小球滤过率（GFR）呈负相关（r=-0.047，P=0.019）；感染与病理类型血管炎呈正相关（r=1.983，P=0.030）。结论应用MMF治疗可增加感染风险，应充分重视。

Objective To evaluate the infection in patients with glomerular diseases treated with mycophenolate mofetile. Methods Totally 47 glomerular diseases patients treated with mycophenolate mofetile, including 39 cases of nephropathy syndrome and 8 cases of systemic vaseulitis, were analyzed. Results During treatment with mycophenolate mofetile for 24 weeks, 15 patients had infections and 3 patients died of infection finally. The infection of upper respiratory tract and pneumonia were common. The logistic regression showed that infection was correlated with glomerular filtration rate （GFR） and systemic vasculitis with the regression coefficients being - 0.047 （P = 0.019） and 1.983 （P = 0.030） respectively. Conclusion Treatment with mycophenolate mofetile could increase the possibility of infection.