蛋白激酶C与糖尿病性及肥厚性心肌病的研究进展

Progresses between Protein Kinase C and Diabetic and Hypertrophic Cardiomyopathy

蛋白激酶C作为第二信使在多条信号通路中发挥着重要作用,并与细胞增殖、分化、凋亡、心肌肥大、心室重塑等有着密切联系。其激活将导致多种心肌病,如糖尿病性心肌病、心肌肥厚和心肌纤维化等心血管疾病的发生。本文对蛋白激酶C与上述几种疾病关系的研究进展予以综述。

Protein kinase C as second messenger plays an important role in multiple signaling pathway, and closely linked with cell proliferation, differentiation, apoptosis, cardiac hypertrophy, ventricular remodeling. Activation of protein kinase C results in many cardiomyopathy, such as diabetic cardiomyopathy, myocardial hypertrophy and cardiac fibrosis as a biological signal transduction protein for many diseases, this article reviewed its latest study with the above mentioned diseases.