慢性阻塞性肺疾病外周骨骼肌功能障碍研究进展

Research Progress on Chronic Obstructive Pulmonary Disease Combined with Peripheral Skeletal Muscle Dysfunction

慢性阻塞性肺疾病(COPD)不仅是肺部炎症和结构的重建,而且是在组织化学和器官功能方面的系统变化,是一个全身性疾病。COPD合并外周骨骼肌功能障碍(PSMD)将进一步限制了患者的活动能力,影响患者生活质量,导致预后更差,预示着更高的病死率。COPD发生PSMD的机制尚不清楚,近来发现过氧化物酶体增殖物激活受体可以影响骨骼肌营养代谢,参与肌纤维转化,在COPD并PSMD中起着重要作用。认识COPD合并PSMD特点及探讨其发生机制,将有助于正确评估患者临床病情,并可能为COPD的预防和治疗提供新的策略。

The pathogenesis of chronic obstructive pulmonary disease（COPD） is not only the lung inflammation and structural reconstruction,but also the changes of histochemistry and organ system functions.It is a systemic disease.COPD combined with peripheral skeletal muscle dysfunction（PSMD） will restrict the activities ability of patients,thus influence the life quality of patients and weaken the prognosis,and further elevate the mortality.The mechanism of COPD combined with PSMD is not clear,the recent discovery of peroxisome proliferator-activated receptors（PPARs）,which can affect nutrient metabolism in skeletal muscle and involve in muscle fiber transformation,play an important role in the development of COPD/PSMD.Understanding the the mechanisms of COPD combined PSMD will contribute to the correct assessment of clinical patients and probably provide new strategies to prevent and treat COPD.