明胶海绵微粒化疗栓塞巨块型肝癌的疗效观察

Therapeutic observation of huge primary hepatoma embolization with gelatin sponge particles combined with epirubicin

目的初步观察应用明胶海绵微粒经肝动脉化疗栓塞(TACE)治疗巨块型原发性肝癌的安全性及近期疗效。方法选用明胶海绵微粒(直径150～350μm和350～560μm)联合化疗药物(吡柔比星,THP)悬浮液化疗栓塞直径>10cm的巨块型肝癌。观察患者术前、术后肿瘤大小改变及并发症。结果12例肝癌患者TACE术后3天CT见瘤体密度显著降低,大部分瘤体呈蜂窝状坏死,1例应用直径150～350μmGPS栓塞瘤体完全液化坏死。术后1个月9例病人瘤体显著缩小,2例稳定,1例肿瘤增大。结论明胶海绵微粒联合化疗栓塞治疗巨块型肝癌。

Objective To study the safety and the short-term efficacy of transhepatic alterial embolization in huge primary hepatoma with gelatin sponge particles combined with epirubicin. Methods gelatin sponge particles was used in the form of 150-350 μm and 350-560μ m cubes. Tumor was embolized completely. Responses of tumor and complications related to embolization were analyzed before and after TACE. Results twelve patients with huge hepatoma were enrolled into this study. After TACE, CT showed deceased tumor density, part of these tumor became gas formation. One month later, tumor size decreased significantly in nine patients, no change in two patients, became larger in one patient. Tumor became liquid completely in one patient treated with 150-350 μ m GSPs. Conclusion TACE by gelatin sponge particles combined with epirubicin is an safe and effective Treatment for huge hepatoma.