自制可脱球囊复制急性巨块型肺栓塞动物模型

The large area pulmonary embolism animal models were formed with self made detachable latex balloons

目的探讨自制可脱球囊行巨块形肺动脉栓塞动物模型的可行性。方法健康绵羊12例,随机分为2组,每组6例。一组以可脱球囊阻塞肺动脉的方式建立模型,另一组为空白对照组。所有动物均有创监测平均动脉压(MAP)、平均肺动脉压(MPAP),无创监测血氧饱和度(SaO2),实验组于肺栓塞模型建立前,之后0.5小时、1小时、2小时取外周动脉血,比较2组血气分析指标变化。所有统计数据采用spss13.0进行处理。结果实验组的绵羊在球囊释放后准确建立急性右肺动脉栓塞模型,出现心率、呼吸频率加快,肺动脉压增高,PaO2和SaO2下降,与对照组有明显统计学差异。对照组无明显改变。结论自制可脱球囊可以快速建立巨块形肺栓塞动物模型,且易于控制,接近临床肺栓塞的病生理状况。

Objective： Study of the feasibility that the large area pulmonary embolism models were formed with self made detachable latex balloons. Methods： 12 healthy sheep were chosen, and divided into 2 groups randomly, 6 in each group. One group had been experimented by Self made detachable latex balloons to form the large area pulmonary embolism models. The other group was blank. All the animals had been monitored the mean artery pressure, mean pulmonary artery pressure and saturation of blood oxygen when the model had been formed in experiment group and 0.5hour, lhour, 2hours after it. The blank group had been also observed along with them. Had been token the arterial blood to get blood gas analysis at the same time. At last, data had been completed by using SPSS 13.0 statistical software. Results： After obstructing the right artery of sheep with self made detachable latex balloons in the experimental group, the large area pulmonary embolism models had been formed. Heart rate and respiratory rate accelerated, the pulmonary artery pressure raised up. The PaO2 and SaO2 had broken down, while in the blank group hadn＇t such change. The statistical difference between experiment group and blank group had been found. Conclusion： Large area pulmonary embolism model can be quickly formed with self made detachable latex balloons by the interventional method. The severity of physiological functions and the accuracy of position can be control easily. ＇l＇he model is more approximate to the PE patient＇s pathological and physiological functions.