国产氨利酮治疗风心病难治性心力衰竭的临床疗效研究

A study on the clinical effect of China-made amrinone in refractory congestive heart failure with rheumatic valve disease

采用漂浮热稀释导管、运动耐量试验等方法,评价18例洋地黄治疗无效的风心病难治性心衰患者口服国产氨利酮15天的疗效。其血流动力学、左右心室功能与用洋地黄时比较获明显改善,运动耐受时间明显延长,临床总有效率94.4%,未发现严重副作用。认为:氨利酮有可能成为治疗风心病难治性心衰的较为理想的药物。

In 18 cases of rheumatic valve disease with refractory congestive heart failure, hemodynamics were measured by invasive technique and tolerance exercise test. Then the China-made amrinone (AMR) was administered for 15 days and all the indices were measured repeatedly. The results showed an improvement in hemodynamics and function of both left and right ventricle. Tolerance exercise time prolonged significantly. The clinical effective rate was 94.4%.No severe side effects were seen. The mechanism of action of AMR was discussed and the effect of AMR on right ventricle was streed.